Preparation of Inclusion Compound of ?-carotene and Study on Its Stability / 中国药房

OBJECTIVE:To prepare the inclusion compound of ?-carotene and study its stability. METHODS: Inclusion compound of ?-carotene with ?-CD was prepared by improved saturated water solution method. The stability of the inclusion compound was investigated by UV spectrophotometry and the content of ?-carotene was determined as well. RESULTS: In the inclusion compound, the content of ?-carotene was 5.54%. The stability of cyclodextrin complexed ?-carotene under heating, exposure to ultraviolet light and oxidizing agent was improved, and the remaining rate of ?-carotene increased by 34.4%, 1.8%, and 64.2%, respectively. CONCLUSION: The stability of ?-carotene was increased after encapsulation with ?-CD.