Feasibility of multi models targeting home pain alleviation service used on 220 cases with advanced cancer / 中华流行病学杂志

Objective To investigate the feasibility and effectiveness of multiple modes on home pain alleviation service used for advanced cancer patients to in prove clinical therapy services.Methods The study was involved with 220 patients with advanced cancers to provide them with multimodal analgesia services at home,from February 2010 to February 2013.Patients in this study had been taking both opioid treatments.They were randomly devided into two groups with the number as 112 and 10g and were given different doses of morphine or other drugs.During the period of observation,data was collected under the M.D.Anderson symptom Inventory (MDASI) score and classification of score on pain.Results Differences of pain scores in the two groups and the MDASI score were significant and presented as skewed distribution.Scores on pain score were between groups were significantly different (Z=-9.735,P＜0.001).The average rankings of A group and B group were 76.68 and 162.79 respectively.Under the application of 0.4 mg alprazolam,the degree of pain alleviation seemed to be better.The differences on comprehensive scores between different drug groups were statistically significant(Z=-13.334,P＜0.001).The average rankings of groups A and B were respectively 59.87 and 179.08.Under the use of 0.4 mg of alprazolam,the results could be considered to show better improvements in symptomatic patients.Application of 0.4 mg alprazolam on patients with advanced-cancer-induced-pain showed a better symptomatic improvement than using morphine.Conclusion Patients with advanced cancers receiving multimodal analgesia short-term sedation therapies at home,showed both ideal feasibility and good effectiveness.When morphine was combined used with midazolam at home,a better outcome could be seen in pain-releasing on patients with cancer,than single morphine analgesia was used.

Manipulation treatment for the thoracic postjoint disorder accompanied by symptoms of coronary artery disease / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the curative effect of the Feng's manipulation on patient with thoracic postjoint disorder accompanied by symptoms of coronary artery disease.</p><p><b>METHODS</b>A total of 180 cases with thoracic postjoint disorder accompanied by symptoms of coronary artery disease were retrospective analyzed from Jan. 2005 to June 2008, included 86 males and 94 females, aged from 18 to 82 years with and average of 43.7 years. The disease course was from 1 d to 40 years with the average of 20.6 months. These patients were divided into 2 groups according to the method of manipulation (group A, n=90) and hot herb (group B, n=90). The patients of group A were treated by manipulation for 1 to 2 times per week. The other group was treated by hot herb for 2 times (20 minutes each time) per day for a month. The symptom and signs (chest distress, precordium pain, cardiopalmus, nape pain, spinous tenderness, tuberculum dolorosum) were compared before and after treatment.</p><p><b>RESULTS</b>All 180 cases were followed up for from 4 to 36 months with an average of 12.7 months. After 1 months of treatment, the chi2 test showed that there was a significant differences between the manipulation therapy group and the hot herb therapy group, including chest distress (chi2 = 8.9322, P = 0.0028 < 0.05); precordium pain (chi2 = 20.6527, P < 0.0001); cardiopalmus (chi2 = 24.2804, P < 0.0001); nape pain (chi2 = 23.5917, P < 0.0001); spinous tenderness (chi2 = 12.2062, P = 0.0005 < 0.01) and tuberculum dolorosum (chi2 = 4.0261, P = 0.0440 < 0.05).</p><p><b>CONCLUSION</b>Manipulation is an effective treatment method for the thoracic post joint disorders.</p>

Quantity and distribution of CD44+/CD24- cells in breast cancer tissue and the cell lines / 中华病理学杂志

<p><b>OBJECTIVE</b>To study the distribution and quantity of CD44+/CD24- cells in breast cancer tissue and the cell lines, and as well as its correlation with the expression of various breast cancer markers and molecular subtyping of breast carcinoma.</p><p><b>METHODS</b>The expression of CD44/CD24, estrogen receptor, progesterone receptor, HER2, human estrogen-induced protein PS2, bcl-2 and nm23 in 60 cases of invasive ductal carcinoma of breast were studied by either single or double immunohistochemical staining. The co-expression of CD44 and CD24 in 3 breast cancer cell lines (MCF-7, MDA-MB-468, and MDA-MB-231) was also examined.</p><p><b>RESULTS</b>The quantity and distribution of CD44+/CD24- cells varied greatly and no specific patterns were identified. The percentage of CD44+/CD24- in breast cancer was 65%. The amount of CD44+/CD24- cells did not correlate with the age of patients, lymph node metastasis, tumor size, molecular subtypes and expression of various breast cancer markers in breast carcinoma. The proportion of CD44+/CD24- cells in MCF-7, MDA-MB-468, and MDA-MB-231 cell lines was <1%, 5% and >80%, respectively.</p><p><b>CONCLUSIONS</b>CD44+/CD24- cells are demonstrated in certain breast cancer tissues and cell lines. However, there is no relationship obtained between the quantity or the distribution of these cells and the molecular subtyping or the clinicopathologic parameters in breast cancer.</p>