Event-related potentials of relational memory in target and delay phases of working memory / 南方医科大学学报

<p><b>OBJECTIVE</b>To compare the spatiotemporal pattern of event-related potentials (ERPs) of relational memory retention between color-location binding and semantics-location binding.</p><p><b>METHODS</b>The ERPs of 19 channels were recorded from 14 healthy subjects while performing the two binding delayed-match-to-sample tasks. A paired-sample t test was used for analysis of both the behavioral performance and ERPs, and statistical parametric mapping (SPM) of the t values was applied to ERPs.</p><p><b>RESULTS</b>Behavioral performances (reaction time and accuracy) in color-location binding were significant better than those of semantics-location binding. The SPM(t) of the ERPs showed significant effects in the middle frontal region and most areas of the parietal lobe (about 200 ms), the bilateral prefrontal and frontal regions (260 approximately 320 ms), and the left occipital region (500 approximately 580 ms).</p><p><b>CONCLUSION</b>Retention of semantics-location relation involves more brain regions than that of color-location relation, and the largest effect occurs in the frontal region.</p>

Nestin activation after rat cerebral ischemia-reperfusion injury and its changes in response to Tongxinluo treatment / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate nestin activation in rat brain subjected to ischemia-reperfusion injury and its changes in response to Tongxinluo treatment.</p><p><b>METHODS</b>Cerebral ischemia was induced by temporary middle cerebral artery occlusion (MCAO) in rats. At 3, 7, 14 and 21 days after MCAO, nestin expression in the ependyma, subventricular zone (SVZ), hippocampal subdentate gyrus zone (HDG) of the rats treated with Tongxinluo were guantified by immunohistochemistry.</p><p><b>RESULTS</b>Compared with the sham operation group, nestin was significantly increased 7, 14 and 21 days after MCAO (P<0.05), and immunofluorescence of BrdU+nestin-positive neurons significantly increased in the SVZ. After treatment with Tongxinluo, the number of BrdU-positive neurons and BrdU+nestin-positive neurons significantly increased as compared with MCAO group (P<0.05).</p><p><b>CONCLUSION</b>Focal cerebral ischemia in the rat results in rapid response and proliferation of neural stem cells in the SVZ and HDG in the ischemic hemisphere, and Tongxinluo may enhance the differentiation and proliferation capacity of the neural stem cells after MCAO.</p>