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Journal of Central South University(Medical Sciences) ; (12): 479-482, 2006.
Article Dans Chinois | WPRIM | ID: wpr-813667

Résumé

OBJECTIVE@#To investigate the relationship between MICA*008/A5.1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality.@*METHODS@#The MICA*008/A5.1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti-HCMV antibody IgM was detected in the serum by ELISA method.@*RESULTS@#The positive rate of MICA*008/A5.1 allele was significantly higher in the control group (56.79%) than that in the kidney transplanted donee group (34.07%) (P <0.05). The infection rate of HCMV in those individuals whose genotype was MICA*008/A5.1 (-) was significantly higher than that in the MICA*008/A5.1(+).@*CONCLUSION@#The individual whose genotype is MICA*008/A5.1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA*008/A5.1 (-) is liable to HCMV infection.


Sujets)
Femelle , Humains , Mâle , Allèles , Anticorps antiviraux , Sang , Chine , Cytomegalovirus , Infections à cytomégalovirus , Génétique , Génotype , Antigènes d'histocompatibilité de classe I , Génétique , Immunoglobuline M , Sang , Transplantation rénale
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