Résumé
[Objective] To investigate the relation among the polymorphism of interleukin-8 (IL-8) gene A-251T and apolipoprotein E (ApoE) gene with late-onset Alzheimer's disease (LOAD). [Methods] Polymerase chain reaction and restrietive fragment length polymorphism (PCR-RFLP) were used to detect the polymorphism distribution of IL-8 gene A-251T and ApoE gene of 185 people in Han ethnicity of Guangdong province (study group: 88 LOAD patients, eontrolled group: 97 people). The correlation of these genes was analyzed. [Results] (1) The differences of genotypes and alleles of IL-8 gene A-251T between study group and controlled group had no statistical significance. (2) The frequency of ApoE 64 allele in study group was significantly higher than that in controlled group, as risk factor of LOAD (OR=2.272, P=0.003). (3) Study group and controlled group were both divided into two groups by carrying ApoE ε4 allele or not. The differenees of IL-8 genotypes were no significant whether in carrying ApoE ε4 allele group or not (carrying ε4 group: P=0.965; no carrying ε4 group: P=0.523). [Conclusion] It is suggested that lL-8 gene A-251T polymorphism perhaps has no relation with LOAD and has no interaction with ApoE ε4 allele.
Résumé
@#Objective To investigate the characteristics of delirium after cerebral infarction in elderly demented patients.Methods40 elderly demented patients with delirium after cerebral infarction were assessed with delirium score scale(DSS),mini-mental state examination (MMSE) during delirium and after delirium disappeared respectively.ResultsThe prominent symptoms from DSS as delirium were disturbance in sleep-awake cycle,speed of onset of behavior change,incoherent thought process,abnormalities of orientation,and misinterpretation of surroundings.The disturbance of sleep-awake cycle and speed of onset of behavior change recovered dramatically as delirium disappeared,however,the abnormalities of orientation and misinterpretation of surroundings mildly improved.The items with lower scores from MMSE as delirium were abilities of attention and calculation,abilities of recall,time disorientation,and three step language orders.The function of language from the items of MMSE improved very well as delirium disappeared,especially the three step language orders,however,the abilities of recall,abilities of attention and calculation,time disorientation mildly improved.ConclusionDetermination of the clinical features of delirium following dementia is helpful to distinguish the delirium from dementia.