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<p><b>OBJECTIVE</b>To screen for KIT gene mutations in two Han Chinese pedigrees affected with Piebaldism.</p><p><b>METHODS</b>Clinical data of the pedigrees was collected. Genomic DNA was extracted from blood samples collected from the pedigrees and 120 unrelated healthy controls. All coding exons of the KIT gene were subjected to PCR amplification and direct sequencing.</p><p><b>RESULTS</b>Two missense mutations, c.1861G>A(p.Ala621Thr) and c.1872G>A(p.Met624Ile), were identified respectively in the two pedigrees. Neither mutation was found among healthy members from the respective pedigree and the 120 unrelated healthy controls. c.1872G>A is a novel mutation.</p><p><b>CONCLUSION</b>Mutations of the KIT gene may affect the structure and function of the transmembrane receptor KIT, which lead to the disease.</p>
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Objective To study the current situation of migrant children' s social adaptation and ex?plore its influencing factors. Methods The study population was 1547 children aged 10?16 years recruited from Shijiazhuang city. Social adaptation was collected through social adaptation questionnaire,whereas self?control was measured by children' s self?control investigating questionnaire. The data were statistically ana?lyzed with the ANOVA and stepwise regression analysis. Results ①There was no significant difference on social adaptation scores between migrant children and urban children (3.71±0.65,3.70±0.69, P>0.05). ②Among migrant children,girls scored significantly higher than boys(3.80±0.59,3.63±0.69, P0.05). Conclusion There is no significant difference on social adaptation between migrant children and urban children. Children' s self?control,parent?child rela?tionship and peer relationship have significant influence on social adaptation of migrant children .
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Objective:To validate the Chinese Version of Depletion Sensitivity Scale (DSS) and test its validity and reliability.Methods:A sample of 499 postgraduates coming from a university in Beijing was investigated with preliminary questionnaire,249 of them were assessed for exploratory factor analysis(EFA) and 250 of them were assessed for confirmatory factor analysis (CFA) and testing of validity and reliability.The criterion validity was tested with the Self-Regulatory Fatigue Scale (SRF-S),Dual-Mode of Self-Control Scale (DMSC-S) and Adolescent Self-rating Life Events Check-list (ASLEC).Totally 280 students were retested for test-retest reliability with 2 week interval.Results:DSS was composed of 8 items in two factors,which were cognitive factor and behavioral factor.The two factors explained 60.7％ of the variances.The confirmatory factor analysis identified a two factor model (x2/df=4.18,RMSEA =0.09,NFI =0.95,NNFI =0.94,CFI =0.96,IFI =0.96,GFI =0.96,SRMR =0.05).The scores of depletion sensitivity were positively correlated with the scores of cognitive fatigue,behavioral fatigue,emotional fatigue poor control,punished,loss,relationship pressure and adaption problem (r =0.13-0.55,Ps ＜0.001).The Cronbach α coefficients were 0.80 for the total questionnaire and 0.79 and 0.73 for the two factors.The test-retest reliability were 0.52 for the total questionnaire and 0.46 and 0.58 for the two factors.Conclusion:It suggests that the Chinese version of Depletion Sensitivity Scale (DSS) is reliable and valid enough to be applicable to measure the depletion sensitivity of Chinese graduate students.
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Objective To examine the differences and influential factors of ego-depletion source and its aftereffects between Chinese and non-Chinese graduate students (international graduate students) enrolled graduate programs in Chinese Universities.Methods Three different questionnaires were employed to assess the current situation of ego-depletion of 647 graduate students:demographic information questionnaire,Ego Depletion Source Scale (EDS-S) in postgraduates and Ego Depletion Aftereffects Scale (EDA-S).Collected data were analyzed by an independent samples t test,correlation analysis and multiple regression analysis.Results ①The scores of non-Chinese graduate students in China (83.59±25.97) were higher than those of Chinese students (67.39± 25.46) on EDA-S in postgraduates,the difference was significant (P＜ 0.01).②The scores of non-Chinese graduate students (132.71± 19.89) were higher than those of Chinese students (104.15±33.02) on EDS-S,the difference was significant (P＜0.01).③Of all the 11 dimensions of EDS-S,social distress,challenging task,thought suppression,compulsive task positively anticipated the EDA-S for Chinese graduate students (R2adj =0.584,R2adj =0.450,R2adj =0.624,R2adj =0.615,P＜0.05) and social distress,decision making,compulsive task positively anticipated the EDA-S for non-Chinese graduate students (R2adj =0.698,R2adj =0 603,R2adj =0.668,P＜0.05).Conclusion Compared to Chinese graduate students,egodepletion source and ego depletion aftereffects of non-Chinese graduate students were higher.Of all the 11 dimensions of EDS-S,social distress,challenging task,thought suppression,compulsive task was in high correlation with EDA-S for Chinese graduate students,and social distress,decision making,compulsive task was in high correlation with EDA-S for non-Chinese graduate students.
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Objective To develop the ego depletion aftereffects scale (EDA-S) and test its validity and reliability.Methods Based on literature analysis and the open questionnaire survey this study compiled the preliminary questionnaire.A sample of 801 subjects coming from a university in Beijing was investigated with preliminary questionnaire and 406 students were retested for test-retest reliability with 2 week interval.Results The EDA-S was composed of 38 items in nine factors,which were emotional regulation difficulty,social withdrawal,low efficacy,working memory impairment,low processing fluency,work burnout,fatigue,somatic distress and low adherence.The eleven factors explained 72.09％ of the variances.Furthermore,the result of CFA indicated that the model fitted the data with well construct validity(x2 =1744.62,df=629,x2/df =2.77,RMSEA =0.06,NFI =0.98,NNFI =0.98,CFI =0.98,IFI =0.98,GFI =0.85,SRMR =0.05) and its factors scores were positively correlated with the SFR-S scores(r=0.31-0.59,P＜0.001).The Cronbach α coefficients were 0.95 for the total questionnaire and 0.73-0.91 for the eleven factors.The test-retest reliabilities were 0.60 for the total questionnaire and 0.26-0.57 for the nine factors.Conclusion It suggests that the EDA-S is reliable and valid enough to be applicable to measure the depletion degree of adolescents.
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Objective To study the effect of parenting styles on the children' s self-control,and distinguish the influence between father and mother.Methods The present study selected 1 531 children (766 girls) between 3-10 years old.Data on parenting style were collected by parenting style questionnaire,while data on children' s self-control were measured by dual-system of self-control scale.Principal component analysis was conducted to examine common method bias.Results (1) No common method bias was found in this study.(2) Boys scored (31.66±5.95) on control system lower than girls (32.91±5.49),t=4.071,P＜ 0.01,but they had higher scores (43.19±8.32) on impulsive system than girls (41.96±8.32),t=2.226,P=0.027.(3)The associations of children's self-control scores with parents' spoiling,neglectful,authoritarian,inconsistent style were significant (r=-0.054～-0.174,P＜0.05),while it correlated positively with parents' democratic style (r=0.231,r=0.243,P＜0.05).The correlation between children's impulsive system scores and parents' spoiling,neglectful,authoritarian,inconsistent style were significantly positive (r=0.116-0.195,P＜0.05),while its associations with parents' democratic style were significant (r=-0.107,r=-0.108,P＜0.05).(4) As controlling children's age and sex,father democracy (β=0.120),inconsistency (β=-0.159),and mother democracy (β=0.188) were significantly correlated with children' s self-control (R 2adj =0.107,P＜0.05).Father despotism (β=0.070),inconsistency (β=0.136),mother's democracy (β=-0.063),despotism (β=0.099) and inconsistency (β=0.061) significantly predicted children's impulsive system (R 2adj =0.082,P＜0.05).Conclusion Each dimension of self-control and parenting style is high correlation.Father and mother's different rearing traits and the combination of different rearing traits contributed variously to children' s self-control system.
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Objective To learn how the process of self-regulatory fatigue (SRF) mediates the effect of leadership styles on job satisfaction of young workers.Methods 723 young workers recruited from a business enterprise were required to response to questionnaire survey, including leader behavior description, self-regulatory fatigue and job satisfaction questionnaire.Results All young workers' job satisfaction was 3.78±0.69,31 years old and above were higher than 30 years old and under(t=-3.246, P＜0.01) ,and there was no significant difference in gender and education.Job satisfaction was significantly positively correlated with leadership style (r initiating structure =0.210, r ideration =0.272), and was significantly negatively correlated with self-regulatory fatigue (r=-0.333).Two dimensions of leadership styles,initiating structure (β=0.227, t=2.659, P＜0.01) and consideration (β=0.270, t=5.035, P＜0.01), had the predicted effects of job satisfaction (R 2 =0.098).Consideration dimension of leadership style had more influence on job satisfaction at the high level of self-regulatory fatigue (β=0.266, t=4.929, P＜0.01);the effect of initiating structure dimention on job satisfaction was influenced by gender (t=-5.154, P＜0.01);self-regulatory fatigue was mediator between leadership styles and job satisfaction, and the consideration dimension of leadership style had more mediation effect on job satisfaction than that of initiating structure dimention of leadership style (mediationconsideration=0.317,mediationinitiating structure=0.268).Conclusion Two dimensions of leadership style can affect job satisfaction, and are mediated by self-regulatory fatigue.The intervention of self-regulatory fatigue can help to improve the job satisfaction of young workers.
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Objective To develop a scale of the executive functional status for adolescents.Methods Regarding to the structure and the conception of executive function and the results of interviews to several adolescents,a preliminary inventory including 37 items was developed.The investigation sample consisted of 1722 students from 2 provinces in China by stratified sampling,and the the internal consistency,conduct validity and criterion validity were assessed by exploratory factor analysis.Results The revised scale including 21 items was consisted of three factors:inhibition control,cognitive flexibility,working memory,which explained 45.39％ of the total variance.The factor loading ranged from 0.499 to 0.727.The Cronbach alpha ranged from 0.786-0.897 for the scale and its three factors.Factor structure fitted actual data and its fit indices were x2=530.44,df=186,RESMA =0.053,GFI =0.93,AGFI =0.91,NFI =0.96,CFI =0.97.Conclusion It shows that the reliability and validity of the scale meet the standard of the psychometrics,and it can be suitable for evaluating the functional status of execution of Chinese adolescent.
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In the process of the introduction of classical problem based learning,the combination of PBL teaching method and current teaching method was found to be abstract and difficult to operate. PBL gradual teaching was brought forward through qestionnaires and analysis. Improved PBL teaching is more suitable for clinical teaching of hepatobiliary surgery in China and helping the interns to get good learning habits. Thus ,it is an effective PBL teahcing method of hepatobiliary surgery.