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Chinese Journal of Cardiology ; (12): 151-155, 2008.
Article Dans Chinois | WPRIM | ID: wpr-299480

Résumé

<p><b>OBJECTIVE</b>The purpose of this study was to determine the feasibility of transcatheter pulmonary valve replacement in sheep up to 6 months post procedure.</p><p><b>METHODS</b>Fresh sheep pericardium treated with a 0.6% glutaraldehyde solution for 36 hours was sutured to a valvular ring and then fixed onto a newly designed nitinol self-expandable stent. Thoracotomy was performed in sheep (23.5 +/- 3.1) kg under general anesthesia and the device was delivered into the native pulmonary valve of the sheep via the anterior wall of right ventricle by catheter and fooled for 6 months.</p><p><b>RESULTS</b>One sheep died 4 months after the procedure due to in-stent thrombosis. Another 4 animals survived the 6-month observing period. Angiographic and hemodynamic measurements confirmed good positioning and function of the stents with a competent valve immediately post procedure and 6 months post the procedure in surviving animals.</p><p><b>CONCLUSION</b>Implantation of the nitinol self-expandable stent in the pulmonary valve position by a transcatheter approach is feasible and good function of transcatheter implanted memory nitinol valved stents was shown after 6 months of implantation in sheep.</p>


Sujets)
Animaux , Femelle , Mâle , Modèles animaux de maladie humaine , Prothèse valvulaire cardiaque , Implantation de valve prothétique cardiaque , Méthodes , Valve du tronc pulmonaire , Chirurgie générale , Ovis , Endoprothèses
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