Optimization of Extraction Technology of Compound Danggui Buxue Decoction by Central Composite Design-Response Surface Method / 中国中医药信息杂志

Objective To optimize extraction technology of Compound Danggui Buxue Decoction. Methods On the basis of single factor test, factorial design, and fastest rise test, yield and weight sum of extraction efficiency of ferulic acid, paeoniflorin and ligustilide were set as response, and central composite design-response surface method was used to optimize the extraction technology of Danggui Buxue Decoction. Results The optimum conditions consisted of ultrasonic-wave extraction for 60 min, ethyl alcohol concentration 36％ and the ratio of material to solvent = 1:94. Conclusion This method has high extraction efficiency, easy operation and good predictability.