1.
Journal of International Oncology
;
(12): 110-112, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-489670
Résumé
More than 50% microRNAs (miRNAs) are located in tumor-associated genome of amplification region or fragile site,which may also act as oncogenes or tumor suppressor gene (TSG).Recently,researches show that the expression of miR-449 is lower in human gastric,lung and ovarian cancer,and may act as TSG.The abnormal expression of miR-449 plays a pivotal role in carcinogenesis and progression,and elucidating its function and regulatory,mechanism can provide valuable diagnostic,prognostic biomarker for cancer management.