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Article de Chinois | WPRIM | ID: wpr-414381

RÉSUMÉ

Objective To assess the associations of 5-HTT gene polymorphism with depression by Metaanalysis.Method A comprehensive search for articles from January 2000 to July 2009 was conducted from Chinese BioMedical Literature Database on disc (CBMdisc) and PubMed databases.All related case-control studies were collected and the results were analyzed using RevMan 4.2.2 software.Results A total of 1284 cases and 1243 controls were collected from 14 studies.The combined data statistics revealed that the pooled ORs ( 95%CI) for genotype SS,SL,LL were 1.64 ( 1.37 ~1.97) (P<0.00001),0.82 (0.66 ~ 1.03) (P>0.01) and 0.74 (0.61 ~ 0.90) (P < 0.01 ) respectively.Conclusions Polymorphisms of 5-HTT gene have significant association with depression,SS genotype may increase the risk for depression,LL genotype may be protective factors for depression.

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