Laparoscopic tubal reconstructive surgery / 한양의대학술지

Tubal and peritoneal factors account for 30% to 40% of cases of female infertility. Tubal factors include damage or obstruction of the fallopian tube. The best technique for diagnosing tubal and peritoneal disease is laparoscopy, and laparoscopic surgery has been used to various tubal conditions (such as laparoscopic fimbrioplasty, salpingectomy, salpingostomy, and tubal reversal). Approximately 1% of the women who undergo tubal sterilization subsequently request reversal of tubal sterilization. Two treatment options are available to women who wished to become pregnant after having tubal sterilization: tubal reversal or in vitro fertilization (IVF). Laparoscopic tubal reversal shows high pregnancy rates similar to laparotomy and superior to the rates reported for IVF. Hydrosalpinx is a common tubal disease that is associated with lower implantation and pregnancy rates. The proper selection of patients for surgical treatment and of the type of surgical technique are essential to achieve good results. For patients with mild tubal disease, good results can be achieved by an experienced surgeon; however, for patients with severe tubal disease, the prognosis of surgery is poor. In these cases, In-vitro fertilization (IVF) is the main line of treatment for infertility caused by hydrosalpinx.

Clinical correlation of basal FSH level and IVF-ET outcome / 대한산부인과학회지

OBJECTIVE: The objective of this study is to evaluate the value of basal follicular stimulating hormone level on clinical outcome in women undergoing IVF-ET. METHOD: A descriptive and retrospective study of 730 cycles of IVF-ET chosen from 2002 to 2004 in CHA fertility center. RESULTS: Basal FSH screening appeared to be a fairly informative predictor of achiving pregnancy especially in GnRH agonist long protocol in women undergoing IVF-ET. In addition, basal FSH level shows significant difference compared ongoing pregnancy with early abortion group in GnRH antagonist group. CONCLUSION: Therefore, we were able to predict the ovarian response and IVF-ET outcome using FSH level. Furthermore, this information allow more precise counseling for patients.

Treatment of Female Infertility

Infertility is a disease that exists when a couple has tried to conceive for 12 months during which time they have had intercourse without the use of contraception. There are many factors suggested as being the causative factors for this problem, and various diagnostic and therapeutic approaches are under practice to alleviate infertility with a great advancement in the molecular biology, cryobiology, assisted reproductive technologies (ART), etc. Earlier evaluation and treatment are required in women with age over 35 years and those with certain medical conditions. The couple should be evaluated at the same time. Stress, which can be manifested as anxiety or depression, is increased in women experiencing infertility. Therefore clinicians need to provide comprehensive care services that are individualized based on the patient's situation, including psychological support and counseling.

Mitochondrial DNA Copy Number in the Patients of Korean Polycystic Ovary Syndrome (PCOS) / 대한불임학회지

OBJECTIVE: We analyzed quantification of mitochondria DNA (mtDNA) to investigate the relationship of mitochondria and pathogenesis of PCOS. MATERIALS AND METHODS: Peripheral blood samples were collected from 28 patients with PCOS who were under the inclusion criteria for PCOS and from 28 healthy controls. Genomic DNA was used to analyze real-time PCR for mtDNA copy number quantification. The mtDNA copy number was compared between the control and PCOS groups. All data was expressed as mean +/- SD. Statistical analysis was assessed by t-test. RESULTS: In this study, the mtDNA CT was 11.67+/-0.422 in PCOS patients and 11.51+/-0.722 in control group, respectively. The mtDNA copy number was 1726410.71+/-407858.591 the patients of in PCOS and 2167887.51+/-252459.28 in control group (p=0.08), respectively. CONCLUSION: In our study, using real-time PCR, there was a tendency of lower mtDNA copy number in the patients of PCOS when comparing to the control group even though statistical difference was not significant. However, more extensive analysis is required to clarity relationship between mtDNA copy number and pathogenesis of PCOS.