1.
Neuroscience Bulletin
;
(6): 118-123, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-300948
Résumé
Neurodegenerative diseases are characterized by the accumulation of intracellular or extracellular protein aggregates that result from conformational changes in proteins. These diseases may result from an imbalance between the production of misfolded proteins and normal chaperone capacity. Molecular chaperones provide a first line of defence against misfolded, aggregation-prone proteins and are, therefore, promising therapeutic targets for neurodegenerative diseases.