A Case of Motor Paralysis Caused by Herpes Zoster / 대한피부과학회지

Motor loss caused by herpes zoster is less well known but occurs in a significant number of cases, probably far more frequent than is recognized because the weakness is readily obscured by pain. The incidence of herpetic motor involvement was reported to be between 0.5% and 31%. A 65-year-old male patient with herpes zoster on the right lower limb had complained with progressive weakness of the limb, during treatment. We examined the limb using electromyographic(EMG) and motor nerve conduction velocity(MNCV) studies. Thereafter we concluded he had motor paralysis caused by herpes zoster. The weakness progressed to the complete motor loss of the right limb. Presenty, he still suffers from the paralysis of the right limb.

A Clinical Study of Androgenetic Alopecia(IV) / 대한피부과학회지

BACKGROUND: Androgenetic alopecia is considered to be a genetically determined disorder influenced by age and androgen. The proportion of patients with androgenetic alopecia among the total number of patients with alopecia seems to be gradually increasing. OBJECTIVE: The purpose of this study was to find the family history, clinical and endocrine status of the patients with androgenetic alopecia. METHOD: 736 patients with androgenetic alopecia who had visited the Department of Dermatology, Yongsan and Pil-dong Hospital, College of Medicine, Chung-Ang University during the last 2 years(1999.1-2000.12) were examined. RESULTS: 1) Incidence of androgenetic alopecia among the total number of alopecia patients was 75.8%. 2) There were 571 male and 165 female patients being most prevalent in the 3rd decade in male patients and in the 4th decade in female patients. 3) In male androgenetic alopecia, Norwood-Hamilton's type II was the most common and following IIIv, II, IV, IIIa, and in female patients, Ludwig's type I was most common. 4) There was a family history of baldness in 59.5% of first degree relatives in male patients and 30.9% in female patients. 5) The most common associated disorder is seborrheic dermatitis. 6) Serum testosterone levels were increased in 78 males(13.7%) and 23 females(13.9%). CONCLUSION: Based on these results, the number of young patients who visit dermatologists tends to be increasing and genetic factor, ages and abnormal androgen metabolism in scalp are affecting the development of androgenetic alopecia.

A Case of Dermatomyositis with Tremor of Upper Extremities / 대한피부과학회지

Dermatomyositis is a rare inflammatory myopathy with characteristic skin manifestations and muscular weakness. Immunologic factors are most likely involved in the pathogenesis of the disease. We describe a 44 year old man with a 5 month history of severe pruritus on the trunk and upper extremities with intermittent tremor of upper extremities. Hydroxychloroquine and methotrexate were combined with glucocorticoids for one month, improvement of clinical manifestations could be observed.

Cutaneous Aspergillosis / 대한의진균학회지

Aspergillosis comprises a spectrum of diseases caused by species of a ubiquitous saprophytic mold, Aspergillus, that usually lives on decaying vegetation. Aspergillus organisms rarely behave as pathogens in an immunocompetent host. But, in the presence of immunosuppression, Aspergillus may be invasive and take a fulminant course. Although extensive investigation has clarified multiple aspects of pulmonary aspergillosis, cutaneous aspergillosis occurs relatively less frequently and therefore remains poorly characterized. With this review, we have attempted to better define risk factors and common clinical presentations, as well as to formulate a reasonable approach to the diagnosis and management of cutaneous aspergillosis.

A Case of Recurrent Kaposi's Sarcoma after Cyclosporine Treatment in Kidney Transplantation Patient / 대한피부과학회지

Kaposi's sarcoma is an unusual neoplasm that has proved to be an enigma in many ways since its original description by Kaposi in 1872. Of the several different type of Kaposi's sarcoma, iatrogenically immunosuppressed patients predisposed to Kaposi's sarcoma are usually either transplant recipients or patients receiving immunosuppressive therapy. We report a case of recurrent Kaposi's sarcoma in a 56 year old male, which has occurred during the cyclosporine therapy of kidney transplantation. Cyclosporine was discontinued and chemotherapy began and the resolution of Kaposi's sarcoma has been obtained. Cyclosporine maintenance therapy was started again for the prevention of graft rejection. But 1 year later, Kaposi's sarcoma recurred probably due to re-use of cyclosporine.

A Case of Verrucous Carcinoma Occurring in Patient with Diabetes Mellitus and Chronic Renal Failure

Verrucous carcinoma is a slow growing, low grade squamous cell carcinoma, which usually occurs on oropharynx, genitalia and soles. When it occurs on feet, it is known as epithelioma cuniculatum. Epithelioma cuniculatum is characterized by its histologic sinuses and cystic formations in a cuniculate(rabbit burrow-like) pattern. A 59-year-old man was consulted to our department for a well circumscribed, 5 × 5 cm sized, round, hyperkeratotic, verrucous plaque on the right great toe. He suffered from diabetes mellitus for 16 years and was managed by peritoneal dialysis three times a week due to chronic renal failure for last two years. The plaque had gradually increased in size. The biopsy specimen taken from the tumor mass showed chronic ulcerative inflammation with atypical squamous cell proliferation. We herein report a case of verrucous carcinoma occurring in a patient with diabetes melli-t tus and chronic renal failure.

A Case of Skin Necrosis due to Adriamycin Extravasation / 대한피부과학회지

Adriamycin extravasation into subcutaneous tissues during intravenous administration results in an intense inflammatory response, which may progress to full thickness skin loss. With increased use of the potent anticancer drug adriamycin, there are increasing numbers of severe local tissue damage at the venous administration sites. We report a case of skin necrosis that was caused by extravasation of adriamycin in the treatment of multiple myeloma. When anticancer drug extravasation occurs, early recognition and adequate management is required.