Résumé
Objective:To study the feasibility of immunomodulation on the patients with severe trauma,sepsis or MODS.Methods:24 patients were divided into control group(A) and therapy group(B) randomly.The control group was given routine therapy while the therapy group was treated with Ulinastatin and thymosin-?1 for 7 days additionally,and two groups were observed for 28 days.Results:Compared with the control group,the expression of CD14+ monocyte HLA-DR in the therapy group increased significantly,while the levels of TNF-?,IL-6 and APACHE Ⅱ score in the therapy group decreased significantly.Conclusions:Treating the patients with thymosin-?1 and Ulinastatin could decrease the levels of TNF-? and IL-6,raise their immunity and improve their prognosis.Immunoregulation treatment is effective for patients with severe sepsis and MODS.