Résumé
Objective To study the effect of the complexus of radix salviae miltiorrhizae and lignstrazin (DCs) on the learning and memory impairment in Alzheimer disease rats. Methods Rats were randomly divided in- to 5 groups(10 rats/group):normal eontrol group, Alzheimer disease model group toxified with AlCl3 and D-gal,3 groups toxified with AICl3 and D-gal,whieh were treated with the different drugs including piracetam and DCs1,2. After 80 days,step-through and morris water maze experiments were used to detect the learning and memory ability. Results Compared with Alzheimer disease model group,DCs obviously improved the learing and memory ability of Alzheimer disease rats,it is increased significantly that active reaction, and the number of active avoidance, improve achievement, evasion failed to reduce the number of passive evade significantly shorten the delay time in Des-treated group. Conclusion DCs markedly improved the learing and memory ability of Alzheimer disease rats.
Résumé
OBJECTIVE:To observe the effects of the compound preparation of Radix et Rhizoma Salviae Miltiorrhizae and Chuanxiongzine(DCs) on activity of superoxide dismutase(SOD),concentration of malondialdehyde(MDA) in erythrocytes and cerebral tissue in rats with Alzheimer's Disease(AD).METHODS:Alzheimer's Disease model was established in rats with aluminium trichloride and D-galactose,with Naofukang as positive control to observe the effects of compound preparation of DCs on the activity of SOD and the concentration of MDA in erythrocytes and cerebral tissue in rats.RE-SULTS:In DCs-treated group compared with Alzheimer's Disease model group,the activity of SOD increased significantly(P