Immunomodulatory effect of beta-glucan derived from Saccharomyces cerevisiae strains / 동물의과학연구지

The aim of this study was to evaluate immunopotentiating activities of beta-glucan derived from Saccharomyces (S.) cerevisiae and to select new strains having possibility as an immune-enhancing substance. We examined SB20 strains derived from commercial product as a control, and extracted beta-glucans from the four strains of S. cerevisiae. RAW264.7 macrophages were treated with heat-killed yeasts, beta-glucans, and lipopolysaccharide (LPS). The production of nitric oxide (NO) and cytokines such as TNF-alpha and IL-1beta were then quantified. When macrophages were induced directly by in vitro addition of beta-glucan, little production of NO and IL-1beta was observed. When pretreated with strong stimulants, i.e., LPS, most yeasts showed down-modulation of NO and IL-1beta production. However, TNF-alpha secretion was triggered by beta-glucans and even more increased by the mixture effect of LPS and beta-glucans. In particular, S6 strain induced TNF-alpha secretion more than other strains. Therefore, we can conclude that the S6 strain has possibility as an immune-enhancing substance.

Anesthetic Management for the patient with Carotid Carotid Artery Aneurysm - 2 case reports / 대한마취과학회지

Aneurysm of the carotid artery in the neck is rare lesion and may elicited in patient with Behcet's disease. To achieve maintenance of critical perfusion pressure of brain during the cross clamping of the carotid body, the anesthesiologist is familiar with the use, reliability and limitation of various monitoring modalities and posses a working knowledge of basic brain physiology and protective measures available to protect against cerebral ischemia and hypoxia. We report here our anesthetic experiences and considerations of 2 surgical patients with both common carotid artery aneurysm and false carotid artery aneurysm associated with Behcet's disease.