Congential t-cell immunodeficiency with post BCG systemic TB infection

Objectives and important to report a case of congenital T-ceIl immunodeficiency with post BCG vaccination systemic TB infection. clinical presentation 6 months old infant presented by respiratory symptoms, light coma, FTT and HSM. Initial investigation CXR showed miliary opacities in both lungs, abdominal U/S showed hepatosplenomegally [HSM] with homogenous echogenicity. CT brain W out contrast showed ventricular dilatation and encephalomalacia and brain distortion, immunological study showed total immunoglobins and IgG, IgM, IgA, IgD, IgE were within normal range. T-lymphocytes showed decrease in total lymphocytes and decease in T4 [T-helper] T8 [T-suppressor] NK [Natural killer] suggests T-cell immunodeficiency. CBC showed microcytic hypochromic anemia[HB 8.5gm/dl] anemia of chronic illness, Screening for IIIV infection negative

Study of thrombomodulin level in infants with respiratory problems of diabetic mothers

In our study, we found statistical significant increase in the soluble form of thrombomodulin PTM was positively correlated to the duration of the disease, age of the mother, PCO2 [in BOA] and CRP. The longer the duration of symptoms, the older the age of the mother or the higher in the PCO2 or CRP +ve, the higher will be PTM. In the other hand, PTM was negatively correlated to gestational age, Apgar score, PH in [BOA], HCO3 in [BGA] and platelet count. The in the Apgar score, PH, HCO3 and platelet count, the lower will be PTM level