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Psychiatry Investigation ; : 1000-1006, 2018.
Article Dans Anglais | WPRIM | ID: wpr-717817

Résumé

OBJECTIVE: Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion. METHODS: Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY). RESULTS: 5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors. CONCLUSION: The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.


Sujets)
Animaux , Rats , 7-Dipropylamino-5,6,7,8-tétrahydro-1-naphtol , Amygdale (système limbique) , Dépression , Hippocampe , Phénotype , Cortex préfrontal , Récepteur de la sérotonine de type 5-HT1A , Agonistes des récepteurs 5-HT1 de la sérotonine , Sérotonine , Contrôle social formel , Isolement social
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