Résumé
OBJECTIVE:To investigate clinical effects of aescuven forte combined with routine drugs in the treatment of vari-cocele(VC). METHODS:A total of 86 patients with VC selected from our hospital during Feb. 2015-Jan. 2016 were divided into control group and observation group according to odd and even number,with 43 cases in each group. Control group was given rou-tine drug therapy. Observation group was additionally given Aescuven forte tablet 300 mg,po,bid,on the basis of control group. Treatment course of 2 groups lasted for 3 months. Clinical efficacies as well as testicular artery blood flow parameters,seminal plas-ma lab indexes and semen quality were compared between 2 groups. The occurrence of ADR was also compared between 2 groups. RESULTS:Total response rate of observation group was 90.70％,which was significantly higher than 72.09％ of control group, with statistical significance (P0.05). Compared to before treatment,testicular artery peak systolic velocity,resistance index and pulsatility index of 2 groups were decreased significantly after treatment,while plasma α-glucosidase,acid phosphatase,Fructose,sperm activate rate of for-ward movement,total sperm activate rate and sperm density were increased significantly;each index of observation group was bet-ter than that of control group,with statistical significance(P0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Aescuven forte combined with routine drug therapy help to improve testicular artery blood flow status of VC patients,regulate the content of semi-nal plasma related molecules and improve semen quality so as to improve clinical efficacy with good safety.