Résumé
OBJECTIVE@#To evaluate the efficacy of specific immunotherapy (SIT) with standardized house dust mite allergen preparation for allergic rhinitis (AR).@*METHOD@#Fifty-five patients with allergic rhinitis caused by house dust mites were selected in this self-control study. Clinical efficacy was evaluated by symptom and sign score after two years of specific immunotherapy and compared with pre-treatment scores.@*RESULT@#After completing the study, a clinically significant reduction in symptom and sign score in these patients was noted, compared with that of pretreatment. And the difference was statistically significant (P < 0.01).@*CONCLUSION@#Standardized house dust mite allergen preparation is an effective treatment in patients suffering from allergic rhinitis due to house dust mites.
Sujets)
Animaux , Femelle , Humains , Mâle , Allergènes , Utilisations thérapeutiques , Antigènes de Dermatophagoides , Utilisations thérapeutiques , Immunothérapie , Méthodes , Pyroglyphidae , Allergie et immunologie , Rhinite allergique , Thérapeutique , Résultat thérapeutiqueRésumé
OBJECTIVE@#To investigate the expression and clinical significance of oncogene AKT2 in laryngeal squamous cell carcinoma (LSCC).@*METHOD@#The expression of AKT2 protein was measured with immunohistochemistry (Elivision two steps) in 60 cases of LSCC tissue, 28 cases of peri-cancer tissue and 16 cases of normal laryngeal epithelium, the relationship between AKT2 expression and clinical pathologic factors in LSCC was also analyzed.@*RESULT@#The positive rates of AKT2 protein expression in LSCC and peri-cancer tissue were 56.7% (34/60), 14.3% (4/28) respectively. There was no expression of AKT2 in normal laryngeal epithelium. The positive rate of AKT2 protein expression in LSCC was significantly higher than that in peri-cancer tissue and normal laryngeal epithelium (P 0.05, respectively).@*CONCLUSION@#AKT2 might play an important role in the tumorigenesis and development of LSCC, and it was suggested that AKT2 could be a useful marker for predicting tumorigenesis, invasion and metastasis potential of LSCC.
Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Carcinome épidermoïde , Métabolisme , Anatomopathologie , Muqueuse laryngée , Métabolisme , Anatomopathologie , Tumeurs du larynx , Métabolisme , Anatomopathologie , Métastase lymphatique , Stadification tumorale , Pronostic , Protéines proto-oncogènes c-akt , MétabolismeRésumé
OBJECTIVE@#To evaluate the curative effect of endoscopic surgery (ESS) in the treatment of inverted papillomas in the nasal cavity and paranasal sinus.@*METHOD@#We report on 16 clinicopathologic cases of inverted papilloma. After preoperative endoscopic examination and CT screening, endoscopic sinus surgery was performed under general anesthesia.@*RESULT@#The follow-up period ranged between one year to two years. Recurrence was observed in 2 cases.@*CONCLUSION@#The nasal endoscopy is a better method for treating Krouse I-II stage nasal inverted papilloma. The advantages of endoscopic surgery include clear visual field, less bleeding, limited reoccurrence, and avoidance of facial incision.