Bidirectional regulation of senescence-associated secretory phenotype on malignant tumors / 中华老年医学杂志

The senescence-associated secretory phenotype(SASP)has bidirectional regulation on tumor cells.However, a comprehensive analysis of the impact of SASP on major malignant tumors is still lacking.This article aims to review the types, characteristics and regulatory roles of SASP in several malignant tumors including liver cancer, breast cancer and prostate cancer, in order to provide a theoretical basis for the mechanisms of occurrence, development, and metastasis of these malignant tumors.