Résumé
OBJECTIVE: To investigate the rationality and trend of utilization of proton pump inhibitors (PPIs) in six areas in China in 2011-2013. METHODS: The utilization of PPIs in Beijing, Chengdu, Guangzhou, Shanghai, Tianjin, and Hangzhou during the period of 2011-2013 were analyzed statistically in respect of consumption sum, DDDs, AARG, DDC, drug interactions, and medical insurance categary. RESULTS: Both the consumption sum and DDDs of PPIs increased quickly in the recent three years. The amount of omeprazole was the greatest and increased steadily. The amounts of rabeprazole and lansoprazole also increased rapidly especially for the domestic products. Medical insurance categary had no obvious effect on clinical choice. PPIs became more cheaper for patients. Rabeprazole and pantoprazole were preferred when PPIs were combined with other drugs, especially in the hospitals which had clinical pharmacist working in the department of gastroenterology or cardiology. CONCLUSION: The use of PPIs tends to be more rational, in which clinical pharmacists play a very important role.
Résumé
OBJECTIVE: To analyze the prevalence of bacterial infection and drug sensitivity after liver transplantation so as to provide reference to effective clinical therapy. METHODS: A retrospective survey of 113 patients who underwent orthotopic liver transplantation was carried out. RESULTS: The reported total incidence of bacterial infection after liver transplantation was 45.1%, while the verified incidence was 28.3%. The major bacterials were Klebsiella pneumoniae and Enterococcus faecom. Multidrug-resistant was observed. CONCLUSION: It is very important to prevent bacterial infection and use antibiotic rationaly. Selection of effective antibiotics according to etiologic data and resistance of bacterial can help prevent the occurance of drug resistant strains.