Avascular necrosis of bone in children with leukemia

A vascular necrosis of the bone [AVNB] is an uncommon serious complication of acute leukemia. Between the years 1997-2007, seven children with acute leukemia of different risk groups presented with symptoms, signs and investigational evidence of avascular necrosis of bone. They were all diagnosed during their maintenance chemotherapy except one patient who had AVNB post-transplant following hematological relapse. Six patients had avascular necrosis of the hip [AVNH], and one patient had avascular necrosis of the foot. Other complications for steroids, such as hyperglycemia were observed in some of the patients. The steroids were omitted in almost all patients immediately. Two patients had surgical intervention and the rest received conservative management. Two patients recovered fully and the rest are still under follow-up at orthopedic clinic pending further management

Precocious puberty in a child with neurofibromatosis

We describe a case of neurofibromatosis type 1 [NF1] of a 5.3 year-old boy who developed precocious puberty at the age of four years. Investigations showed a secondary CNS origin of his sexual precocity