Relation of factor VIII and IX inhibitors with ABO blood groups in 150 patients with haemophilia A and B

Many investigations have proved relations between ABO blood groups with some diseases and factor VIII and von willebrand level in plasma. In this study we investigated a relation between ABO blood groups and factor VIII and IX inhibitors in 102 patients with haemophilia A and 48 patients with haemophilia B. The assay of inhibitor was done by Bethesda method. There were no relation between ABO blood groups and factor VIII and IX inhibitors

Factor V and VIII inhibitor in patients with combined factor v and VIII deficiency

Patients with coagulation factor[s] deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor[s]. In this survey we detected factor V and VTQ inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran [Khorassan province]. It was revealed in our survey that eight patients had both factor V and factor VIII inhibitors and two patients had none. Because factor V and factor VIII share approximately 40% amino acid sequence homology in their A and C domains, it remains to be elucidated if it is one molecule that recognizes both factor V and VIII or whether there are two inhibitor molecules against common sites