Esophageal lichen planus stricture

Lichen planus is a dermatologic chronic inflammatory disease that usually involved the skin and mucosa. Esophageal lichen planus with stricture is rare presentation of this disease. It is usually associated with oral mucosal involvement and commonly presenting in middle-age female. In present case, we describe a 48-year-old woman with history of oral lichen planus who referred to us for progressive dysphagia for solid food .She had not history of other causes of dysphagia. Upper endoscopy revealed a benign stricture located in proximal of esophagus that comparable with lichen planus features. The patient underwent three sessions of wireguided bougie dilation that improved her symptoms totally. Lichen planus has to be considered in differential diagnosis in patients with dysphagia

Association of Helicobacter Pylori Infection with Colon Polyp and Colorectal Cancer.

Background/Objective: Helicobacter pylori (Hp) is an etiology of gastrointestinal problems like gastric cancer. Its role in colorectal cancer is under investigations. Therefore, in this study we proposed the association of Hp infection with colon polyp and colorectal cancer. Methods: Patients who referred to Gastrointestinal Clinic of Firoozgar Hospital, Tehran, Iran from May 2014 to March 2015, were enrolled in a prospective case control study. Two groups of colorectal cancer (CRC) and colon polyps were compared with a group of healthy individuals. All participants underwent endoscopy, total colonoscopy, PCR test for Hp, Rapid Urease Test (RUT), stomach histological sections, anti- Hp IgG, CagA protein expression, and serum gastrin levels. SPSS v.20.0 used to analysis of variables. Results: a total of 240 participants, 138 (57.5%) males and 102 (42.5%) females, were divided into three groups of colon polyp (66/240), CRC (58/240), and health control (116/240). Results of PCR for Hp detection in colon samples were negative in all three groups. The association of presence of colorectal cancer and positive RUT in stomach was not significant (p=0.09). There was no significant relationship between positive Hp in the stomach and the site and the type of polyps in colon and anti- Hp IgG, CagA protein expression and serum gastrin levels of three groups (p>0.05). Conclusion: Our findings revealed that the Hp infection does not show a significant association with CRC and colon polyps.