Review of the application of neonatal maternal separation model in irritable bowel syndrome (IBS) studies / 中国实验动物学报

The neonatal maternal separation ( NMS) model has been ubiquitously used in studies of irritable bowel syndrome ( IBS) ,which mimics the disease characterized by visceral hypersensitivity, and GI dismotility and mental disor-der.This minireview focuses on the features and certain pathological mechanism of the animal models.