Résumé
Contribution of neuroinflammation and epilepsy in the mature brain has elicited contradictory results with either excitatory or inhibitory effects. The amygdala is one of the main parts of the limbic system susceptible to insults that lead to neuroinflammation and epilepsy. This study evaluates the effect of chronic inflammation of the rat amygdala induced by lipopolysaccharide [LPS] on kindling epileptogenesis. LPS [5microg/rat] was infused once daily into the basolateral amygdala [BLA] of adult rats. Daily electrical stimulation [150-300 microA, 100 Hz, monophasic square wave stimulus of 1 msec per wave, 2 sec duration] was delivered into BLA 30 min after LPS injections until the animals became fully kindled. LPS had no significant effect on the development of focal and generalized seizures. The type of neural system exposed to LPS and its specific electrophysiological properties seems to ascertain the final excitatory or inhibitory outcome
Résumé
Initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. The purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves. NMRI mice [n = 200] with injured left paw, caused by crushing their sciatic nerves, were randomly selected. The animals were exposed to ultrasound radiation with various frequencies, intensities, and exposure time. They were allocated into 20 groups [19 treatment and 1 control groups]. Sciatic functional index [SFI] test was used to evaluate the difference between the groups with respect to functional efficiency of the sciatic nerve and its recovery. The results of SFI test obtained from the 14th day showed a significant difference among the groups [P<0.05]. On the 14th day after treatment, one of the groups [US11] recovered up to 90%. Altered ultrasound exposure parameters had more favorable outcomes compared with our previous work