Public health risk assessment of imported infectious diseases in Jinhua / 预防医学

Objective@#To carry out an assessment on the public health risk of imported infectious diseases in Jinhua, so as to provide evidence for prevention and control strategies.@*Methods @#Twenty-nine imported infectious diseases were recruited. A risk assessment index system was established by Delphi method and analytic hierarchy process. The actual values of each index of twenty-nine imported infectious diseases were obtained through special investigation,literature review and consultation. The risk scores were calculated by the improved technique for sequencing by approximate ideal solution (TOPSIS) and classified according to median.@*Results @#Among 41 experts recruited, 38 experts were engaged in infectious disease prevention and control, 31 had senior professional titles, and all had worked for more than 10 years. Through three rounds of consultation by Delphi method and analytic hierarchy process, the risk assessment index system (target level) included four items in criteria levels, which were response capacity, public health impact, the possibility of import and local transmission and population vulnerability in a descending order of weight; twenty-seven indicators, with international attention level, levels of medical institutions with confirmed cases, the emergency response capacity of Centers for Disease Control and Prevention (CDCs) , and effective vaccines with wide coverage weighed higher. There were eleven high-risk diseases, high response capacities lay in dengue, malaria, Zika virus disease and Chikungunya fever. The response capacities for sixteen of the eighteen low-risk diseases were insufficient, especially in emergency response capacity of CDCs, laboratory testing capacity and hospital infection control ability.@*Conclusion@#Jinhua has strong capacities to deal with the incidence of dengue fever, malaria, Zika virus disease and Chikungunya fever, compared with other imported infectious diseases.

Salvianolic acid A alleviates the renal damage in rats with chronic renal failure

Abstract Purpose: To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF). Methods: The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules of both kidneys were removed. The rats in group CRF+SAA were intragastrically administrated with 10 mg/kg SAA for 8 weeks. The blood urine nitrogen (BUN), urine creatinine (Ucr), creatinine clearance rate (Ccr), and serum uperoxide dismutase (SOD) and malondialdehyde (MDA) were tested. The expressions of transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 7 (BMP-7) and Smad6 protein in renal tissue were determined. Results: After treatment, compared with group CRF, in group CRF+SAA the BUN, Scr, serum MDA and kidney/body weight ratio were decreased, the Ccr and serum SOD were increased, the TGF-β1 protein expression level in renal tissue was decreased, and the BMP-7 and Smad6 protein levels were increased (all P < 0.05). Conclusion: SAA can alleviate the renal damage in CRF rats through anti-oxidant stress, down-regulation of TGF-β1 signaling pathway and up-regulation of BMP-7/Smad6 signaling pathway.

Efficacy of modified endoscopic release in treatment of carpal tunnel syndrome / 中国内镜杂志

Objective To explore a new technology system with single-portal and without special equipment to complete the arthroscopic treatment of carpal tunnel syndrome. Methods All the patients with CTS were randomly divided into two groups, modified endoscopic carpal tunnel release (MECTR) group (22 cases) and open carpal tunnel release (OCTR) group (24 cases). Nine parameters were evaluated, which including operation time, intraoperative complications, two-point discrimination 3 months after the operation, hospitalization time, scar pain score, incision infection rate, each patient's symptom amelioration (Kelly grading), the time needed to resume normal lifestyle and activity, symptoms of sympathetic dystrophy. Results No significant difference was observed between the MECTR group and OCTR group in regard to incision infection rate, intraoperative complications, two-point discrimination,symptoms of sympathetic dystrophy and clinical symptoms amelioration. In comparison to OCTS, MECTR significantly decreased operation time, hospitalization time, scar pain score and the time needed to resume normal lifestyle and activity. Conclusion MECTR for treatment of carpal tunnel syndrome has higher patient satisfaction, shorter operation time and hospitalization time, earlier return to work or normal lifestyle, less postoperative scar pain, so it is an effective method for the treatment of idiopathic carpal tunnel syndrome.