Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To investigate hereditary susceptibility to coronary heart disease (CHD) in apolipoprotein E(apo E) and apo B polymorphisms of youths.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze apoE, apoB Xba I, apoB 3' variable number of tandem repeat (VNTR) genotypes for 244 healthy Han students (among them were 109 students with positive CHD family history).</p><p><b>RESULTS</b>The allele frequencies of apo e4, XbaI x(+), 3'VNTR-B(hypervariable element, HVE>38) in the positive group were obviously higher than those in the negative group(P<0.05), and were significantly correlated with the increase in TC, LDL-C, apoB100 levels (P<0.05).</p><p><b>CONCLUSION</b>The alleles for apo e4, XbaI x(+), 3'VNTR-B may be the important genetic markers of Han CHD.</p>