Résumé
The microbial resistance has become a global hazard with the irrational use of antibiotics. Infection of drug-resistant bacteria seriously threatens human health. Currently, there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of [S,Z]-4-methyl-2-[4-oxo-5-[[5-substitutedphenylfuran-2- yl] methylene]-2-thioxothiazolidin-3-yl]pentanoic acids via a Knoevenagel condensation were synthesized and evaluated for their antibacterial activity in-vitro. The synthesized compounds were characterized by IR, [1]H NMR and MS. The antibacterial test in-vitro showed that all of the synthesized compounds had good antibacterial activity against several Gram-positive bacteria [including multidrug-resistant clinical isolates] with minimum inhibitory concentration [MIC] values in the range of 2-4 micro g/mL. Especially compounds 4c, 4d, 4e and 4f were the most potent, with MIC values of 2 micro g/mL against four multidrug-resistant Gram-positive bacterial strains