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Chinese Pharmacological Bulletin
; (12): 321-324, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-705040
Résumé
Tumor suppressor p53 protein can regulate the tran-scription of target genes, to control cell apoptosis, aging and other life activities,but mutant p53 is prone to losing antitumor function, thus promoting tumor development. At present, p53 protein has become one of the hot targets for the treatment of cancer. This article mainly introduces the structure and mechanism of small molecular compounds with restoring activity of mutant p53 as the target.