Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Journal of Southern Medical University ; (12): 2218-2220, 2008.
Article Dans Chinois | WPRIM | ID: wpr-321724

Résumé

<p><b>OBJECTIVE</b>To investigate the effects of different anesthesia methods on immune surveillance and tumor metastasis in tumor-bearing rats.</p><p><b>METHODS</b>Seventy-two Fischer 344 rats were randomly assigned into 3 equal groups and anesthetized for 1 h with ketamine (group K), propofol (group P), or neuraxial block (group B). All the rats were subjected to laparotomy followed by intravenous injection of MADB106 tumor cells, and 24 h after the injection, the number and activity of circulating CD3(+), CD4(+), CD8(+), and D4(+)/CD8(+) lymphocyte subsets and NK cellèCD161a(+)éwere assessed. Three weeks later, the lung metastases were counted.</p><p><b>RESULTS</b>Compared with those in group B, the numbers of CD3(+), CD4(+), CD8(+), and CD161a(+) lymphocytes and the activity of circulating NK cells were significantly reduced, and the lung metastases of MADB106 increased significantly in groups K and P (P<0.05 or 0.01 ). The activity of immune surveillance in group K was significantly lower than that in group P except for CD8(+) cells, and the tumor metastases in group K increased significantly in comparison with those in group P (P<0.05 or 0.01).</p><p><b>CONCLUSION</b>Neuraxial block provides protection of the activity of immune surveillance and reduces tumor metastases in tumor-bearing rats compared with general anesthesia.</p>


Sujets)
Animaux , Femelle , Mâle , Rats , Anesthésie péridurale , Anesthésie générale , Tumeurs du sein , Allergie et immunologie , Chirurgie générale , Surveillance immunologique , Allergie et immunologie , Kétamine , Pharmacologie , Tumeurs du poumon , Allergie et immunologie , Métastase tumorale , Transplantation tumorale , Bloc nerveux , Propofol , Pharmacologie , Répartition aléatoire , Rats de lignée F344
SÉLECTION CITATIONS
Détails de la recherche