Case Analysis and Pharmaceutical Care for a Patient with Chemotherapy-inducedⅣDegree Myelosuppres-sion / 中国药师

Objective:To investigate the breakthrough points and methods of pharmaceutical care performed by clinical pharma-cists for chemotherapy-induced Ⅳ degree myelosuppression. Methods: One advanced lung adenocarcinoma patient suffering from IV degree myolosuppression after being treated with pemetrexed combined with nedaplatin was selected as the example, and the chemother-apy regimen, the cause and treatment of IV degree myolosuppression and the pharmaceutical service could be carried out were ana-lyzed. Results: With the help of clinical pharmacists, the patient conquered chemotherapy-induced myelosuppression, and clinical pharmacists enhanced the awareness of pharmaceutical care and played a positive role in the safe and effective drug use. Conclusion:The participation of clinical pharmacists in clinical pharmaceutical care through providing pharmaceutical service is beneficial to safer and more effective drug therapy.

Determination of Concentrations of Tacrolimus in Whole Blood With ELISA and Its Application / 中国药房

OBJECTIVE:To discuss the accuracy of detecting tacrolimus(FK506) concentration in whole blood by ELISA and its application in organ transplantation.METHODS:The ELISA was used to detect FK506 valley point concentrations in 5 liver transplanted recipients at different postoperative periods .Based on the results combined with clinical findings, the dosages were adjusted.The accuracy of the method and guidance action in FK506 clinical application were described.RESULTS: In 131 detections of 350 samples, the results of quality control samples were all in the control range .The detecting RSDs of high and low concentration quality control samples were 9.09% and 11.90%, respectively.The control range of FK506 concentrations in whole blood were similar to that reported in literature .CONCLUSION :ELISA is a sensitive and specific method for routine FK506 concentration monitoring in whole blood,which is suitable for application in hospital.

Several Problems about Drug Management in Drug Clinical Trial Process / 中国药房

OBJECTIVE:To provide reference for drug management in clinical trial process in hospital. METHODS:To summarize the common problems of current drug control in clinical trial process and analyze their harmfulness. Some countermeasures were put forward to resolve those problems. RESULTS & CONCLUSIONS:At present uniform management mode hasn’t been established for drug control in clinical trial institutions. Realizations on the importance of drug control are different from one another. There are several factors which affect clinical trials even result in undesirable consequence. The institution should formulate scientific,effective and practical management standards and operation process to improve the quality of drug control and ensure safety, scientificity and reliability of clinical trials.

Review of Adverse Reactions Induced by Quinolone Antibacterial Agents Reported During the Period 1985～1997 / 中国药房

OBJECTIVE: To properly evaluate the conditions of clinical practice of quinolone antibacterial agents. To provide data for clinical medicine and to guide rational drug use. METHODS: 237 cases with adverse reactions induced by quinolone antibacterial agents reported in demestic literatures issued from 1985 to 1997 were collected and statistically ana- lyzed. RESULTS: The general rule and characteristics of occurrence of adverse reactions resulted from quinolones have been summarized. CONCLUSION: The indications for clinical use of quinolones should be handled strictly, especially in children, so as to avoid the abuse of drug.