Résumé
@#Fibroblast activating protein (FAP) is an important biomarker of cancer associated fibroblasts and activated fibroblasts, which is highly expressed in activated fibroblasts of many tumor and fibrotic tissues, but not in normal tissues and non malignant lesions. Therefore, FAP has become an excellent target for diagnosis and treatment of tumors and other diseases. PET imaging and internal radiotherapy based on FAP inhibitor (FAPI) have been used in the diagnosis and treatment of many diseases, such as cancer and fibrosis. We first introduce the mechanism of disease occurrence and progression mediated by FAP and its clinical significance as a therapeutic target.Then,we systematically summarize the FAP probes labeled with 125I, 68Ga, 64Cu and other radionuclides, including their structural evolution, imaging, biodistribution and pharmacokinetic properties.After that, the reported strategies to improve the pharmacokinetic properties and target affinity of probes are summarized, including the use of squaramide linkers,modification with albumin binding agent,the development of dual-targeting probes.Finally, some suggestions for the future development of novel radioactive probes targeting FAP and the clinical application of classical probes are proposed.
Résumé
The 210-layer consecutive CT Dicom format image of a healthy human body thoracolumbar was directly reading into the Mimics,and defining bone organization threshold,withdrawing each outline,partitioning each edge of layer picture,selectively editing and repairing by hole processing.After the redundancy data was cleaned,the thoracolumbar 3-D finite element geometry model was acquired.Then area mesh could be introduced into Ansys software directly to compartmentalize mesh body,and then transferred the body mesh to mimics to assignment on the basis of CT values,then add the ligaments and joint-bindings to perfect the 3D finite element model in Ansys.Then bound the lower of L_1 and impose displacement-load in the upper edge of T_(12).The 3D finite element model was reconstructed using CT images from a patient of T_(12) and L_1 vertebral compression fractures.After that,a realistic appearance and calculation accuracy 3-D bone finite element model of thoracolumbar was established.The results showed that reconstructing a three-dimensional finite element model of thoracolumbar spine compression fractures based on fracture mechanism by information from normal human is scientific and effective.