Study on Quality Standard for Huashengping Capsules / 中国药师

Objective:To establish the quality standard for Huashengping capsules. Methods: Milkvetch Root, Hedyotis diffusa Willd and Salvia miltiorrhiza were identified by TLC. The content of astragaloside A was detected by HPLC. The column was Kormasil C18(250 mm ×4.6 mm, 5 μm) and the flow rate was 1.0 ml·min-1. The mobile phases was a mixture of acetonitrile-water (32∶68 ) . The detection wavelength was 203 nm. The column temperature was 25℃ and the sample size was 20μl. Results:The TLC chro-matography spots were clear. Astragaloside A was linear within the range of 2. 000-10. 000 μg(r=0. 999 6) and the average recovery was 100. 8%(RSD=1. 9%,n=6). Conclusion:The method is simple, accurate and reliable, which can be used in the quality con-trol of Huashengping capsules.

Preparation and Per Cutem Permeability Test of Ketoprofen Poultice / 中国药房

OBJECTIVE:To optimize the matrix formulation of ketoprofen cataplasm and to investigate its influencing factors.METHODS:Orthogonal design was used to design formulations,adhesive stress was tested with the tension meter and the per cutem permeability in vitro was studied using the franz diffusion cell.RESULTS:The optimal poultice was acquired with adhesive stress at40N and steady permeation flux at9.72?g/(cm 2 ?h).CONCLUSION:The established preparation technique of poultice is stable and feasible,and its leading influencing factors are adhesive stress and transdermal effects.

Study on the Optimization of Prescription and Preparation of Matrine Liposomes / 中国药房

OBJECTIVE:To optimize the prescription and preparation of matrine liposomes.METHODS:The liposomes were prepared by the reverse-phase evaporation technique;the envelope efficiency and the diameter of matrine liposomes were taken as criteria,the prescription and preparation of the liposomes were optimized by orthogonal design.RESULTS:The best prescription consisted of egg phosphatidylcholin(80mg),the oil phase cholesterol(15mg),the water phase phosphate buffer so?lution(pH=7.0)and matrine(30mg);the best preparation technics was as follows:chloroform(30ml),ultrasonic time was10min rotary evaporating temperature at48℃.The liposomes had homogeneous shape with the particle size at250nm～750nm and the envelope efficiency of matrine liposomes at47.25%.CONCLUSION:The optimized formulation of martine liposomes is reasonable in prescription,practicable in technics,high in envelope efficiency and perfect in stability.