Résumé
Objective:To respond to the national requirements on the construction of research integrity, and improve the capacity building of research integrity at hospitals.Methods:Dealing with research integrity problems identified at hospital before 2018, measurements that include " policy and procedures development, standardization of the management of scientific research activities, and optimizing the scientific and technological evaluation system" were adopted to promote the construction of research integrity. Such corrective activities were monitored to summarize experiences and lessons for the continuing improvement of research integrity construction.Results:Both " heteronomy" and " self-discipline" of research integrity have been sublimated simultaneously, at the same time, a tailored research integrity management system with the characteristics of local hospitals has been established.Conclusions:Updating institutional policy and procedures, taking paper management as a priority, as well as research integrity training, these measurements played important roles in promoting the research integrity capacity building at hospitals.
Résumé
To determine fluoride in toothpaste samples by ion chromatography,the solution of NaHCO3 and the solution of Na2B4O7-NaOH were selected as eluents respectively to optimize chromatographic detection conditions. Either the 0. 45～1.0 mmol/L NaHCO3 solution or the 5.0～20. 0 mmol/L NaB4O7-1. 0～2.0 mmol/L NaOH solution as eluents could effectively separate the chromatographic peak of fluoride in toothpaste samples from acetate and formate and accurately quantify the contents of fluoride in toothpaste samples. The recovery rates,precision(relative standard deviation) and detection limit were 92.5％～100. 2％ ,＜0. 6％ and 0. 208 mg/kg respectively. The data obtained by ion chromatography using NaHCO3 solution as eluent more approached to that by selective-fluoride-ion-electrode.
Résumé
0.999).The relative standard derivations (RSDs) were 0.2%-5.0%, the rates of recovery were 91.1%-108.5%. The detection limits for analysis ranged from 1.3 mg/kg to10 mg/kg. Conclusion The method presented in the paper is sensitive, accurate and suitable for the determination of organic acids cosmetic samples.
Résumé
Objective To establish an IC method for determination of iodate, bromate, nitrite in cosmetics, food and salt by suppressed anion-exchange chromatography and ion-exchange with the addition of post column reagent. Methods A high capacity anion exchange column, Ion Pac9-HC column was used by 9 mmol/L sodium carbonate as eluent, and the flow rate was set up at 1.3 ml/min,an auto-suppression external water mode was used, 0.5 g/L o-dianisidine. 2HCl(ODA)+5 g/L KBr+20%methanel+5.6% nitric acid was used as post column reagent , the flow was set up 0.7 ml/min. The post column reaction (PCR) temperature was 60 ℃ and the visible absorbance detection at 450 nm. Samples were pretreated and analysed. Results The influence of pH of samples and coexist anion on determination was discussed. The detection limit(MDL) of the present method was 0.008-0.10 mg/kg, the recovery rates of the method were 92.0%-109.0% and the relative standard deviation (RSD) were 0.1%-7.2%. Conclusion This method is accurate, sensitive and suitable for trace analysis (?g/kg) of cosmetics and foods samples.