Non-compaction cardiomyopathy in a 5-generation Chinese family / 中华心血管病杂志

<p><b>OBJECTIVE</b>Familial left ventricular noncompaction(LVNC) is quite rare. We screened for the presence of LVNC and related clinical characteristics in a 5-generation Chinese family.</p><p><b>METHODS</b>Comprehensive medical history was obtained from 40 members in a 5-generation Chinese family. Systemic clinical investigations including echocardiography (UCG), routine and ambulatory electrocardiogram (ECG), X-rays were performed in 33 family members. Cardiovascular magnetic resonance image (MRI) was carried out in 2 family members.</p><p><b>RESULTS</b>Sudden cardiac death (including 1 occurred while following-up) was reported in 7 family members (17.5%, 7/40). LVNC was diagnosed in 10 out of the 33 family members (30.3%) and heart enlargement was evidenced in 3, heart failure in 2, complete left branch conductive block in 3, serious sick sinus syndrome (SSS) treated with permanent pacemaker implantation in 1 and paroxysmal supraventricular tachycardia treated with radiofrequency ablation procedure in 1 out of these 10 LVNC patients. Primary pedigree analysis revealed that offspring from female patients were at the highest risk to be affected by LVNC (15/18, 83.3%) while LVNC was absent in offspring of male LVNC patients (0/8). Moreover, clinical heart failure symptoms and arrhythmias were more severe in female LVNC patients than in male LVNC patients.</p><p><b>CONCLUSION</b>Primary familial investigation reveals the matrilineal inheritance of familial LVNC in this 5-generation Chinese family, further investigations are warranted to explore the potential mutations in the mitochondrial genome responsible for LVNC in this family.</p>

Biocompatibility evaluation of domestically-manufactured NiTi-alloys after thermal oxidation of surface / 第二军医大学学报

Obiective: To compare the tissue biocompatibility of domestically manufactured NiTi alloy before and after thermal surface oxidation under 3 different temperatures. Methods: Domestically manufactured NiTi alloy was oxidized in air (group A) and subjected to 30 min heat treatment at 400°C (group B),500°C, (group C),and 600°C (group D) to form different protective oxide surface layers in presence of argon (607.95 kPa). Wire samples from A, B, C and D groups were subcutaneously implanted in guinea pigs. Guinea pigs received 317L stainless steel transplantation(group E) and sham-operation group (F) were taken as control. The order of inflammatory cell infiltration and tissue hyperplasia around implanted materials were observed 1, 2, 4, and 8 weeks after implantation. Results: The peak time of inflammatory cell infiltration and fibrous hyperplasia were at the first and fourth week after implantation. The inflammatory cell infiltration and fibrous hyperplasia were both slight and all met the GB/T 16886. 6-1997 in vivo implantation standard. The order of inflammatory cell infiltration and thickness of capsule walls from low to high was F

Biocompatibility evaluation of domestically-manufactured NiTi-alloys after thermal oxidation of surface / 第二军医大学学报

Objective:To compare the tissue biocompatibility of domestically manufactured NiTi alloy before and after thermal surface oxidation under 3 different temperatures.Methods:Domestically manufactured NiTi alloy was oxidized in air (group A)and subjected to 30 min heat treatment at 400℃(group B),500℃(group C),and 600℃(group D)to form different protective oxide surface layers in presence of argon(607.95 kPa).Wire samples from A,B,C and I3 groups were subcutaneously implanted in guinea pigs.Guinea pigs received 317L stainless steel transplantation(group E)and sham-operation group(F)were taken as control.The order of inflammatory cell infiltration and tissue hyperplasia around implanted materials were observed 1,2,4,and 8 weeks after implantation.Results:The peak time of inflammatory cell infiltration and fibrous hyperplasia were at the first and fourth week after implantation.The inflammatory cell infiltration and fibrous hyperplasia were both slight and all met the GB/T 16886.6-1997 in vivo implantation standard.The order of inflammatory cell infiltration and thickness of capsule walls from low to high was F