Résumé
Objective:To investigate and compare the influence of systemic inflammation score(SIS) and modified glasgow prognostic score(mGPS) on patients undergoing radical surgery for gallbladder cancer.Methods:A cohort study was used to collect the clinical data of total 50 patients with gallbladder cancer who underwent radical surgery in Zhongda Hospital Affiliated to Southeast University from March 2010 to March 2020. Survival analysis was utilized to assess the impact of SIS and mGPS for prognosis.The predictive accuracy of each score was compared by means of subgroup analysis and time dependent receiver operating characteristics analysis.Measurement data with normal distribution were expressed as mean±standard deviation( ± s), and t test was used for comparison between groups. Count data were expressed as cases and percentages (%), and chi-square test was used for comparison between groups. Results:The 1-, 2-and 3-year survival rate of 50 gallbladder cancer patients undergoing radical surgery were 76%, 55%, 37.6%. Cox multivariate analysis showed SIS score ( HR=2.072, P=0.014) was independent prognostic risk factor; Time dependent ROC curve analysis found that the area under the SIS curve was significantly greater than the mGPS at postoperative 1 year (0.748 vs 0.603, P=0.024); Subgroup analysis found in advanced patients, SIS score was statistically significant compared with mGPS ( P=0.03). Conclusions:SIS is superior to mGPS for predicting OS in patients with gallbladder cancer who underwent radical surgery, and SIS is an independent risk factors for prognosis of patients with gallbladder cancer.
Résumé
Gallbladder carcinoma is a kind of malignant tumor induced by many factors with high mortality.The pathogenesis of gallbladder cancer is still unclear.Surgical resection is the first choice of treatment.With the development of minimally invasive technology,laparoscopy is more and more widely used in the treatment of gallbladder carcinoma with its unique advantages.However,the indication of laparoscopic surgery in patients with gallbladder cancer hasn't been standardized around the world.By reviewing the relevant literature in recent years,the causes of gallbladder carcinoma and the problems related disputes in laparoscopic surgery are summarized and discussed in order to provide guidance and basis for the future laparoscopic cholecystic carcinoma surgery.