The total terpenoids of Celastrus aggravate DNA damage and induce apoptosis of gastric cancer cells by inhibiting Chk1 / 中国药理学通报

Aim To explore the inhibitory effect of the on gastric cancer cells from the perspective of DNA total terpenoids of Celastrus orbiculatus Thunb (TTC) damage response. Methods CCK-8 experiment was conducted to investigate the toxic effects of different concentrations

Progress in targeted therapy of tumor KRAS gene mutation / 中国药理学通报

Targeting KRAS mutations has always been a difficult issue in clinical tumor therapy as most tumors are accompanied by KRAS gene mutations, which indicate poor prognosis. The mutant KRAS protein is difficult to design specific inhibitors in the conventional way of inhibiting the active sites, which is known as "undmggble" target. Therefore, the exploration of drug strategies targeting KRAS mutations has become a hot spot in the research and development of antitumor drugs. Although the research progress of targeted KRAS treatment strategy is limited, some new strategies that directly or indirectly inhibit mutant KRAS are still emerging in view of the deepening understanding of KRAS mutation function and malignant mechanism. In this review, we discussed the research progress of targeted therapy for KRAS gene mutation in tumor, hoping to provide the latest clues for the treatment of KRAS mutant tumor.