Résumé
The hypotensive effect of PAMC and its mechanism were studied.In conscious renal hypertensive rats, intraperitonal injection of PAMC once a day for 7d at the dosage of 11 mg/kg ( 1 time/day ) and oral administration of the drug 3 times a day for 14 d at the dosage of 12 mg/kg/d, the arterial pressure decreased 29.0?2.8% and 20.3 ? 1.4%, respectively.In normal anesthetized dogs and rats, intravenous injection of PAMC at the dosage of 0.4 mg/kg, the mean arterial pressure deceased 43.7 ? 7.9 and 39.7 ? 2.3%. In anesthetized rabbits and rats, intraduodenal injection of PAMC at the dosage of 4 mg/kg, the mean arterial pressure decreased 24.5 ? 3.8% and 38.2 ? 11.4%, respectively.The experiments suggested that inhibition of the (?) -adrenal receptors may be the principal mechanism of the hypotensive action of PAMC. Ganglion blockade, vasodilation as Well as excitation of ?2-adrenal receptors may also be involved.The acuts iv PAMC LD50 in mice were 25.5?5.0 mg/kg.
Résumé
Dicarboxyethyl Germanium Sesquioxide ( DEG ) is a organic germanium compound of artificial synthesis. It could inhibite gastric lesions in pylorus-tightened rats, increased the levels of PGE2 and markedly reduced pepsin activity and free acid of gastric juice. DEG also inhibited formation of indomethacine, pentagastrin and alcohol induced ulcer. It could accelerate the healing of acetic acid ulcer, but couldn't against acute stress and reserpin produced gastric ulcer. The secretory reaction of chief cell of DEG groups were reduced markedly than control. To sum up, the prineiple mechanism of anti-gastric ulcer of DEG may be by raising the levels of PGE2 in gastric juice and inhibiting pepsinia and promoting synthesis of protein.