Predictors of recurrence of febrile seizures in childhood

Febrile seizures in childhood is a common problem. All physicians must know risk factors of recurrence of such problem. To determine the neurologic predictors and risk factors that influence the recurrence of febrile seizures in infants and children. Study included 25 cases aged 8 month to 7 years, all were subjected to full neurological examination and questionnaire for: 1- Family history. 2- Onset of first seizure. 3- Types of seizure and EEG pattern. 4- Neuro-psychological abnormalities. 2 groups of infants and children: group One [14 cases]: Age at onset of fit < 15 months, 10 cases had- ve family history for seizures, while 4 cases had+ve family history of seizures. Only 2 cases of this group had slight retarded Psychomotor development. Group two: [11 cases]: With age at onset of seizures > 15 months, 7 cases had no family history of seizures while 4 had+ve family history. No cases of neuropsychological retardation were noted in that group. EEG was done for all patients 10 cases [3 of group one and 7 of group two] had normal EEG. 10 cases [7 of group one and 3 of group two] had focal epileptogenic activity. 5 cases had different types of EEG abnormalities. Different neurological predictors of recurrence of febrile seizures in childhood: 56% of cases in our study had seizures< 15 month and +ve family history of seizures as well as delay is psychomotor development and EEC changes are important to anticipate recurrence of febrile seizures

Study of kidney function in asphyxiated full term newborn

Renal impairment in the neonates usually occurs following complicated labor and delivery with perinatal asphyxia, and it is usually in form of tubular insult. [Al Fred, 1996]. The clinical presentations of renal impairment in neonates is often subtle, lack of recognition of its occurrence has made this especially true when renal impairment follows perinatal asphyxia. To study kidney function in full term asphyxiated neonates. 24 asphyxiated FT newborn and 12 control were subjected to comprehensive history and renal function evaluation study. Routine urinalysis of cases, with perinatal hypoxia revealed proteinuria in 41.7% in patients. Many epithelial cells were found in 53.5% of the cases with perinatal asphyxia. Mean urine analysis for R.B.Cs of patients [6.33 RBCs/HPF +/- 4.02 RBCs/HPF]' which was significantly higher than that of controls [4.16 RBCs/HPF +/- 2.69 RBCs/HPF]. Mean urine analysis for pus cells of patients [2.84 pus cells/HPF +/- 1.59 pus cells/HPF] which was not significantly different than that of controls [3.08 pus cells/HPF + 3.87 pus cells/HPF]. Mean urinary beta 2 micro globulin concentration in patients [218.30 ng/ml +/- 100.93 ng/ml] was significantly higher than that of controls [144.316 ng/ml +/- 126.3 ng/ml] which is specific for tubular renal insult in renal impairment. Mean urinary urea in patients was [7.727 + 3.16 meq/l] which was not significant in relation to controls 96.80 +2.907 meq/l]. Mean urinary creatinine in patients was [1.30 +1.4 meq/l] which was not significantly different than controls [1.22 +1.09 meq/l]. Renal function must be evaluated in all asphyxiated newborn serum cratinine and heamaturia are sensitive indicators while urinary beta2 microlobin is more specific

Can we use serum interleulkin -1 beta in diagnosis of early neonatal sepsis?

Neonatal sepsis is an important cause of morbidity end mortality with a predictably poor outcome unless early diagnosis and appropriate treatment serum interleukin -1 beta can be used to diagnose early neonatal sepsis. serum samples of interlukin -1 beta of 80 neonates: 20 FT healthy and 20 PT as control 20 FT septic and 20 preterm septic the study is to evaluate specificity and sensitivity of that test to predict neonates with early sepsis. All cases were admitted to NICU and Nursery in Ahmed Maher Teaching Hospital. No significant difference in serum interleuk in 1-beta in comparing the diseased FT group and the control FT group. While there was significant increase in serum interleukin 1-beta in septic preterun group. As well as there was significant correlation between serum level IL-1 beta and maternal infection as a maternal risk factor. Seurm level of interleukin-1-beta can aid in laboratory diagnosis of early sepsis in preterm neonates but not of value in early sepsis of FT ones