Progress of physiological dysfunctions in autism spectrum disorder / 国际儿科学杂志

Autism spectrum disorder(ASD)is a group of highly heterogeneous neurodevelopmental disorders with different kinds of physiological dysfunctions.Based on the literature reports, physiological dysfunctions of ASD mainly focus on four aspects, including immune dysregulation/ inflammation, oxidative stress, mitochondrial dysfunction and environmental toxin exposure.This review focuses on the main manifestations of the four physiological abnormalities in patients with ASD, aiming to illustrate the relationship between various physiological abnormalities and autism, providing clues for the research, treatment and prevention strategies of ASD.