Résumé
Objective To discuss the role of FAT2 gene in the ovarian epithelial carcinoma (OEC) and predict and analyze the possible mechanism and clinical value of FAT2 in the occurrence and development of ovarian cancer. Methods Data of 311 patients with OEC in the TCGA database were analyzed by cbioprotal online analysis platform. Kaplan-Meier method was used to analyze the relationship between the FAT2 genetic alteration and ovarian cancer survival. The FAT2 gene related proteins, protein network and enrichment analysis were performed by GeneCards database. Results In 311 patients, mutation of FAT2 gene was found in 12 patients with a mutation rate of 4%, amplification in 7 cases (2.3%), multiple mutations in 3 cases (1%) and deletion in 2 cases (0.6%). Kaplan-Meier curve showed that the total survival of patients with FAT2 genetic alteration was significantly longer than that in patients without FAT2 genetic alteration (P=0.0338). There was no significant difference in the disease-free survival time between the two groups (P=0.387). Twenty-one FAT2 related protein, such as CTNNB1, ARVCF and CTNND1 were down expressed in OEC tissues. The FAT2 related protein enrichment was analyzed, and Wnt signaling pathway, cell-cell adhesion and other cell physiological activities were found. Conclusion FAT2 may play the role in cancer suppressor gene in OEC, which induces the degradation of key protein CTNNB1 in Wnt pathway. The Over expression of FAT2 might be a good prognostic factor in ovarian cancer and can be used as a potential prognostic marker and a therapeutic target.
Résumé
Objective To study clinical ultrasonography characteristics on parathyroid cysts , so as to avoid misdiagnosis of that in clinic . [ Methods] The ultrasonic image data on parathyroid cyst of 3 misdiagnosed cases hospitalized from June 2012 to May 2013 were retrospectively analyzed . [ Results] The foci of 3 cases were located in the dorsal area under the left lobe distal polar of thyroid , and were con-firmed by surgery and pathology .The common performance of ultrasonic images:round or oval anechoic ar-ea, clear boundary , integrity membrane , thin and smooth wall .The envelop between parathyroid cyst and thyroid presented with acute angle . [ Conclusion] In thyroid ultrasonic examination , lesions in the par-athyroid gland area , especially around the inferior pole of thyroid , should be considered to be differentiated from that of parathyroid disease .