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Braz. j. infect. dis ; 24(2): 144-149, Mar.-Apr. 2020. tab, graf
Article Dans Anglais | LILACS, ColecionaSUS | ID: biblio-1132435

Résumé

ABSTRACT In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7% of MS patients (508/560) were seropositive for HHV-6, while 82.3% (461/560) of healthy subjects were seropositive for this virus (p = 0.001). Moreover, there was a significant increase in the levels of MMP-2, MMP-9, and lower vitamin D in the serum samples of MS patients when compared with healthy subjects. Additionally, we demonstrated that the MMP-9 levels in seropositive MS patients were significantly higher than seronegative MS patients (p = 0.001). Finally, our results demonstrated that the mean of expanded disability status scale (EDSS) in seropositive MS patients was significantly higher in comparison to seronegative MS patients (p < 0.05). In conclusion, we suggest that the HHV-6 infection may play a role in MS pathogenesis.


Sujets)
Adulte , Femelle , Humains , Mâle , Adulte d'âge moyen , Vitamine D/sang , Infections à roséolovirus/sang , Matrix metalloproteinase 2/sang , Matrix metalloproteinase 9/sang , Sclérose en plaques/sang , Test ELISA , Herpèsvirus humain de type 6/immunologie , Infections à roséolovirus/complications , Anticorps antiviraux/sang , Sclérose en plaques/complications
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