Résumé
Fast Disintegrating Tablets [FDTs] is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients]
It is also developed with the aim of improving bioavailability and patient compliance
During the present study, cefadroxil fast disintegrating tablets formulations [n=9] were designed and optimized by central composite design with two independent variables [croscarmellose and crospovidone] using design expert® software
The effects of independent variables on formulation properties such as friability, hardness, in vitro dispersion and disintegration were assessed by drawing response surface graphs with design expert® software. Tablets were assessed for pharmacopeial and non-pharmacopeial parameters to ensure the quality of compressed tablets
Among all formulations, F3, F8 and F9 have shown better results. The formulation F9 containing 15mg croscarmellose and !l075mg crospovidone showed good pharmacotechnical attributes as well as shelf life. F 9 showed improved dissolution with t90o/0 of> 2 min and will lead to better bioavailability