Résumé
Objective · To discuss the relationship between unexplained recurrent spontaneous abortion (URSA) and T follicular helper (Tfh) cell subtypes. Methods · Twenty-eight normal early pregnancy women, who had undergone induced abortion, were taken as control, and 28 patients with URSA were enrolled in the abortion group. The mononuclear cells in peripheral blood and decidual tissues were separated in the two groups, and CXCR3+CCR6- Tfh cells, CXCR3-CCR6- Tfh cells, CXCR3-CCR6+ Tfh cells and B cells were tested by flow cytometry. Results · The decidual CXCR3-CCR6- Tfh cells significantly increased in the abortion group compared with control group (P=0.015). And there was a strong association between the decidual CXCR3-CCR6- Tfh cells and B cells in URSA patients (R2=0.779, P=0.025). Conclusion · The up-regulation of decidual CXCR3-CCR6- Tfh cells in early pregnancy women may be related with the occurrence of URSA.
Résumé
Objective To investigate the Yangwei granules on Hp positive chronic erosive gastritis and inflammatory factors in the patients with HP negative rate effect. Methods 92 Hp positive patients with chronic erosive gastritis from February 2015 to June 2016 were randomly divided into control group and study group, 46 cases respectively. The control group was given Hp eradication standard scheme; the study group to Yangwei granules treatment. The levels of serum IL-2R, IL-6, TNF-α, and Hp were compared before and after treatment. Results Compared with the control group, serum IL-2R, IL-6, TNF-α alpha of the study group after treatment is lower. The negative rate of Hp in the control group was 69.57%, and the negative rate of Hp in the study group was 89.13%, (P<0.05). The effective rate of the control group was 73.91%, and the effective rate of the study group was 91.31% (P<0.05). Conclusion Yangwei granule can reduce inflammation in patients with Hp positive chronic erosive gastritis the reaction, improve the clinical efficacy and eradication rate of Hp, high safety.
Résumé
Objective · To discuss the relationship between unexplained recurrent spontaneous abortion (URSA) and T follicular helper (Tfh) cell subtypes. Methods · Twenty-eight normal early pregnancy women, who had undergone induced abortion, were taken as control, and 28 patients with URSA were enrolled in the abortion group. The mononuclear cells in peripheral blood and decidual tissues were separated in the two groups, and CXCR3+CCR6- Tfh cells, CXCR3-CCR6- Tfh cells, CXCR3-CCR6+ Tfh cells and B cells were tested by flow cytometry. Results · The decidual CXCR3-CCR6- Tfh cells significantly increased in the abortion group compared with control group (P=0.015). And there was a strong association between the decidual CXCR3-CCR6- Tfh cells and B cells in URSA patients (R2=0.779, P=0.025). Conclusion · The up-regulation of decidual CXCR3-CCR6- Tfh cells in early pregnancy women may be related with the occurrence of URSA.
Résumé
Objective To investigate the Yangwei granules on Hp positive chronic erosive gastritis and inflammatory factors in the patients with HP negative rate effect. Methods 92 Hp positive patients with chronic erosive gastritis from February 2015 to June 2016 were randomly divided into control group and study group, 46 cases respectively. The control group was given Hp eradication standard scheme; the study group to Yangwei granules treatment. The levels of serum IL-2R, IL-6, TNF-α, and Hp were compared before and after treatment. Results Compared with the control group, serum IL-2R, IL-6, TNF-α alpha of the study group after treatment is lower. The negative rate of Hp in the control group was 69.57%, and the negative rate of Hp in the study group was 89.13%, (P<0.05). The effective rate of the control group was 73.91%, and the effective rate of the study group was 91.31% (P<0.05). Conclusion Yangwei granule can reduce inflammation in patients with Hp positive chronic erosive gastritis the reaction, improve the clinical efficacy and eradication rate of Hp, high safety.