Research advances of histone deacetylases in inflammatory respiratory diseases / 解放军医学杂志

Histone deacetylases (HDAC) are pivotal enzymes in many physiological processes widely expressed in almost all tissues including chromatin remodeling,regulation of protein transcription,cell cycle,aging,oxidative stress,inflammation and expression of immune genes.Recent studies indicated that the equilibrium state of histone acetylation and deacetylation is closely related to respiratory tract inflammation,and the unbalanced expression of HDAC could induce the expression of genes related to the inflammatory cytokines and oxidative stress.Now the structure and classification of HDAC and the updated results on HDAC in the inflammatory respiratory diseases are herewith reviewed in present paper.