Résumé
Objective To compare two pretreatment plan QA methods for HalcyonTM accelerator using Portal Dosimetry (PD),and PTW OCTAVIUS 1500 detector array + Octagonal phantom (Oct 1500)respectively.Methods Parallel measurement-based pretreatment QA using two methods was performed for 22 IMRT/VMAT plans (74 fields) that have been used to treat 20 patients recruited in the Halcyon clinical trial.Several γ 2D comparisons were also applied to provide guidelines for Halcyon planning QA.Results Using Oct1500 method,the γ 2D passing rates for 74 fields in 22 Plans were 95.26±3.59,95.01±3.62 (Local Dose),99.05± 1.35,98.57± 1.96 (Max Dose) respectively.Two-related samples non-parametric tests suggested that the differences between the evaluation criteria were of statistical significance (Z =-7.220,-4.108,P＜0.05).For PD method,the γ 2D passing rates were 84.11％ ± 1.35％ (1 mm/1％),99.07％± 1.35％ (2 mm/2％),and 99.86％ ± 1.35％ (3 mm/3％).Two-related samples non-parametric tests suggested that the differences between evaluation criteria of PD method were statistically significant (Z =-7.475,-7.475,-6.906,P＜0.05).For 74 fields and max dose,3 mm/3％ evaluation criteria,two-related samples non-parametric tests suggested that the differences between PD and Oct1500 method were statistically significant (Z=-5.072,P＜0.05).Conclusions Both methods can be used for Halcyon pretreatment plan QA.PD is superior to Oct1500 with respect to efficiency and spatial resolution-induced verification accuracy.The criteria of 2 mm/2％ for PD,and Max Dose/3 mm/3％ for Oct1500 was suggested.
Résumé
Aims: The behavior of laboratory animals has been studied through displacement, with different objectives by researchers. Methods: Although different methods have already been used in the tracking of laboratory animals, manual tracking mode videogrammetry for 2D analysis of displacement has not been observed in animal studies. The aim of this study was to verify the accuracy and reliability of determining the displacement of Wistar rats by means of videogrammetry software Dvideo. The accuracy (between the known distance and distance traced) was determined by 3 different evaluators twice consecutive, by videoing a course of 10 meters in the enriched environment together with further analysis of the displacement of the midpoint marked on an apparatus. To calculate reliability (accuracy of the measurement system) and reproducibility (precision of the evaluators) to obtain the ratio of precision to tolerance (P/T), eight animals were filmed for 10 minutes in the enriched environment and analysis of distance covered by one of the animals by three different reviewers thrice consecutive. Results: The results obtained in the course of 10 meters of the known distance demonstrated accuracy of 0.10 m, precision of 0.05 m, and bias of 0.07 m. In the reliability test during the 10 minutes of displacement (m) of animal, the ratio of precision to tolerance (P/T) = 0.1 m was found between three different evaluators, demonstrating adequate capacity of the measure. Conclusion The manual tracking mode of the Dvideo presented high reliability and it can be employed for the displacement analysis of studies with rat experimental models.(AU)