Résumé
Objective: To study the chemical constituents from plant of Artemisia frigida Willd. and its pharmacological activities. Methods: The compounds were isolated and purified by various chromatography methods. All compounds were identified by spectroscopic and chromatographic techniques, and were screening for their PPARγ activating activity and PTP1B inhibitory activity. Results: There were 26 compounds isolated from the plant of A. frigida and identified as pectolinarigenin (1), jaceosidin (2), chrysoeriol (3), tricin (4), 3-oxogermacra-1(10),11(13)-dien-6α,12-olide (5), achillin (6), 1,10β-epoxyachillin (7), scoparone (8), 4-hydroxyacetophenone (9), chrysosplentin (10), jaceidin (11), 11α,13-dihydroyomogin (12), chrysanthemin A (13), eupatilin (14), eupatrin (15), artemorin (16), 6-methoxytricin (17), hanphyllin (18), cirsimaritin (19), ridentin (20), desacetylmatricarin (21), subchrysine (22), luteolin (23), caffeic acid (24), agastachoside (25), and tilianin (26). Conclusion: Compounds 5, 7, 11, 18, 25, and 26 are firstly isolated from the Artemisia. Compounds 10, 12, 13, 16, 17, and 22 are firstly isolated from this plant. Compounds 2 and 15 exhibited weak activity of PPARγ. Compounds 1 and 3 had inhibitory effect on PTP1B.