Evaluation of Anti-inflammatory activity of Qurs-e-Mafasil Jadeed.

With an increased incidence of drug toxicity and resistance to allopathic drugs, plant drug formulations could be an interesting alternative. Some plant drugs and phytochemicals are known to be anti-inflammatory properties, and can be of great significance in treatment of inflammatory disorders. These considerations require the scientific evaluation of the most important and commonly used traditional herbal formulations. A study has been done to find anti-inflammatory activity of Qurs-e-Mafasil Jadeed containing Colchicun luteum, Curcuma longa and gum of Acacia Arabica. In this proposed work 2 % aqueous suspension of qurs/tablet powder in gum acacia was used to determine its anti-inflammatory activity by carrageenin induced oedema test and cotton pellet induced granuloma test. Efficacy of this Unani formulation was compared with standard referent drug, Diclofenac sodium. The obtained results using carrageenin oedema test showed decrease in left hind paw volume significantly after 3 hours of carrageenin injection. In cotton pellet induced granuloma test, animals in all the test and standard drug tested groups, shows reduction in granuloma formation significantly. Thus, our results clearly indicate that this test formulation possesses significant anti-inflammatory activity in both acute and sub-acute phase.

Validation of defluoridation method with “acacia arabica” plant byproduct through 2n factorial experimentation-A statistical approach.

Adsorption is one of the most efficient physicochemical processes known to remove fluoride from drinking water. Activated carbon adsorption is conventionally the most used material for this purpose. The aim of this study was to know the variables that influence the adsorption process of fluoride ion from aqueous media, so as to optimize the operating conditions. Factorial experimentation within a certain domain was used to determine the influence level of several parameters, such as initial pH of the solution, particle size, adsorbent’s concentration agitation time and their interactions. A statistical analysis of the results showed that within the selected domain all the parameters have influence at a significance level of 1% excepting initial pH that only has influence at a significance level of 5 %. Some of the possible interactions between these parameters also have significant influence on the adsorption process especially first order ones, including significance levels of 5 and 1%. This means then that optimization of operating conditions water treatment using the studied adsorption technique will not imply additional costs. This emphasizes the importance of Acacia arabica fruit carbon as an alternative to activated carbon.